volume 16 of biological magnetic resonance (modern techniques in protein nmr) represents significant advances in the biomolecular nmr field, with emphasis on developments during the recent years. this book brings together some of the worlds foremost experts who have provided broad leadership in advancing the field. volume 16 is devoted to topics on biomacromolecules and pulse methods. it covers advances in the study of large proteins and protein complexes, methods involving perdeuterated large proteins, membrane proteins, advances in pulse schemes for spin decoupling and for the measurement of coupling constants and torsion angle constraints including cross-correlated relaxation spectroscopy.