in this volume, each of the six naphthyridine systems are described: primary synthetic methods from non-naphthyridine substrates; chemistry and properties of the parent heterocycle and its simple alkyl derivatives; formation and reactions of halogeno derivatives; formation and reactions of hydroxy, oxo, alkoxy, and related derivatives; formation and reactions of mercapto, thioxo, alkylthio, and related derivatives; formation and reactions of nitro/amino derivatives and related derivatives; formation and reactions of the naphthyridinecarboxylic acids, esters, amides, and realted derivatives. in addition, tabulateddata on all known simple naphthyridine derivatives is presented.