Name: Formulation and Development of Bilayer Floating Tablets of Nifedipine (en Inglés)
Price: 68.83 USD
Availability: InStock
Author: Sharma, Dinesh Kumar ; Behera, Amulyaratna ; Pattnaik, Gurudutta
ISBN: 9786203410877

portada Formulation and Development of Bilayer Floating Tablets of Nifedipine (en Inglés)

Formato

Libro Físico

Autor

Gurudutta Pattnaik

Amulyaratna Behera

Dinesh Kumar Sharma

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

108

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.7 cm

Peso

0.17 kg.

ISBN13

9786203410877

Categorías

Farmacología

Formulation and Development of Bilayer Floating Tablets of Nifedipine (en Inglés)

Gurudutta Pattnaik (Autor) · Amulyaratna Behera (Autor) · Dinesh Kumar Sharma (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Formulation and Development of Bilayer Floating Tablets of Nifedipine (en Inglés)"

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.