Name: 2-Pyrazoline-1-Carboxamide Derivatives (en Inglés)
SKU: 63478097
Price: 78.99 USD
Availability: InStock
Author: Azizur Rahman Md; Anees A Siddiqui

portada 2-Pyrazoline-1-Carboxamide Derivatives (en Inglés)

2-Pyrazoline-1-Carboxamide Derivatives (en Inglés)

Formato

Libro Físico

Editorial

Lap Lambert Academic Publishing

Autor

Azizur Rahman Md; Anees A Siddiqui

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

ISBN13

9786208119034

2-Pyrazoline-1-Carboxamide Derivatives (en Inglés)

Azizur Rahman Md; Anees A Siddiqui (Autor) · Lap Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "2-Pyrazoline-1-Carboxamide Derivatives (en Inglés)"

2-Pyrazoline derivatives are synthesized by diverse reaction schemes and display a broad spectrum of potential pharmacological activities. The derivatives are present in numerous pharmacologically active molecules such as azolid/ tandearil (anti-inflammatory), phenazone/ amidopyrene/ methampyrone (analgesic and antipyretic), anturane (uricosuric) and indoxacarb (insecticide). New therapeutic agents having improved potency and lesser toxicity are developed by changing in their structure, and it has offered a high degree of diversity that has proven useful for the new drug development. The aim of the present research was thus focused on 2-pyrazoline-1-carboxamide derivatives. The 2-pyrazoline-1-carboxamide derivatives were synthesized by convenient, economical methods in less reaction time and with better yield of products with high level of purity. The compounds numbered 4d-4e, 4j-4k, and 4m-4t were most protective against MES even at 30 mg/kg dose levels. The synthesized compounds were showing minimal neurotoxicity. Thus, it is concluded that all the tested compounds are protective against MES at 100-300 mg/kg dose levels and show promising anticonvulsant activity.