Name: 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents (en Inglés)
SKU: 57256247
Price: 80.74 USD
Availability: InStock
Author: Sidat, Parin S. ; Noolvi, Malleshappa ; Beldar, Vishal G.
ISBN: 9786139448050

portada 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents (en Inglés)

5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents (en Inglés)

Formato

Libro Físico

Autor

Parin S. Sidat

Malleshappa Noolvi

Vishal G. Beldar

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

120

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.7 cm

Peso

0.19 kg.

ISBN13

9786139448050

Categorías

Química

5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents (en Inglés)

Parin S. Sidat (Autor) · Malleshappa Noolvi (Autor) · Vishal G. Beldar (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents (en Inglés)"

In search of new anticancer agents we have reported the synthesis of some 1,3,4-thiadiazoles. While designing target molecules, we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other's. Furthermore also characterized and confirmed by IR, 1H-NMR, and Mass spectral. For anticancer activity, all the selected compounds were submitted to NCI (National Cancer Institute) for in vitro anticancer activity. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compound 5(a) and (6b) showed good activity against the all cancer cell lines at NCI, USA