Name: A Mathematical Modeling Framework to Simulate and Analyze Cell Type Transitions (en Inglés)
SKU: 62069440
Price: 89.46 USD
Availability: InStock
Author: Daniella Schittler
ISBN: 9783832539351

portada A Mathematical Modeling Framework to Simulate and Analyze Cell Type Transitions (en Inglés)

A Mathematical Modeling Framework to Simulate and Analyze Cell Type Transitions (en Inglés)

Formato

Libro Físico

Editorial

Logos Verlag

Autor

Daniella Schittler

Idioma

Inglés

N° páginas

189

Encuadernación

Tapa Blanda

ISBN13

9783832539351

A Mathematical Modeling Framework to Simulate and Analyze Cell Type Transitions (en Inglés)

Daniella Schittler (Autor) · Logos Verlag · Tapa Blanda

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Reseña del libro "A Mathematical Modeling Framework to Simulate and Analyze Cell Type Transitions (en Inglés)"

The quantitative understanding of changes in cell types, referred to as cell type transitions, is fundamental to advance fields such as stem cell research, immunology, and cancer therapies. This thesis provides a mathematical modeling framework to simulate and analyze cell type transitions. The novel methodological approaches and models presented here address diverse levels which are essential in this context: Gene regulatory network models represent the cell type-determining gene expression dynamics. Here, a novel construction method for gene regulatory network models is introduced, which allows to transfer results from generic low-dimensional to realistic high-dimensional gene regulatory network models.For populations of cells, a generalized model class is proposed that accounts for multiple cell types, division numbers, and the full label distribution. Analysis and solution methods are presented for this new model class, which cover common cell population experiments and allow to exploit the full information from data. The modeling and analysis methods presented here connect formerly isolated approaches, and thereby contribute to a holistic framework for the quantitative understanding of cell type transitions.