portada Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (en Inglés)

Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (en Inglés)

Formato

Libro Físico

Autor

Wenfei Jin

Editorial

Springer

Idioma

Inglés

N° páginas

114

Encuadernación

Tapa Blanda

Dimensiones

23.4x15.6x0.7 cm

Peso

0.20 kg.

ISBN13

9789402404302

Categorías

Anatomía
Fisiología
Genética médica
Matemáticas aplicadas
Biología, ciencias de la vida

Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (en Inglés)

Wenfei Jin (Autor) · Springer · Tapa Blanda

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Reseña del libro "Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (en Inglés)"

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.