portada Atorvastatin Self-Emulsified Tablets Formulation and Evaluation (en Inglés)

Atorvastatin Self-Emulsified Tablets Formulation and Evaluation (en Inglés)

Formato

Libro Físico

Autor

Prasanta Kumar Biswal

Prafulla Kumar Sahu

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.5 cm

Peso

0.12 kg.

ISBN13

9786205528082

Categorías

Farmacología

Atorvastatin Self-Emulsified Tablets Formulation and Evaluation (en Inglés)

Prasanta Kumar Biswal (Autor) · Prafulla Kumar Sahu (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Atorvastatin Self-Emulsified Tablets Formulation and Evaluation (en Inglés)"

Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).