Name: Cellular Entry of Binary and Pore-Forming Bacterial Toxins (en Inglés)
SKU: 57931666
Price: 64.93 USD
Availability: InStock
Author: Ladokhin, Alexey S.

portada Cellular Entry of Binary and Pore-Forming Bacterial Toxins (en Inglés)

Cellular Entry of Binary and Pore-Forming Bacterial Toxins (en Inglés)

Formato

Libro Físico

Editorial

Mdpi AG

Autor

Ladokhin, Alexey S.

Idioma

Inglés

N° páginas

128

Encuadernación

Tapa Blanda

Dimensiones

24.4x17x0.9 cm

Peso

0.29 kg.

ISBN13

9783038427049

Categorías

Biología, ciencias de la vida

Cellular Entry of Binary and Pore-Forming Bacterial Toxins (en Inglés)

Ladokhin, Alexey S. (Autor) · Mdpi AG · Tapa Blanda

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Reseña del libro "Cellular Entry of Binary and Pore-Forming Bacterial Toxins (en Inglés)"

Bridging cellular membranes is a key step in the pathogenic action of both binary and pore-forming bacterial toxins. The former use their translocation domains, containing various structural motifs, to ensure efficient delivery of the toxic component into the host cell, while the latter act on the cellular membrane itself. In either case, the integrity of the membrane is compromised via targeted protein-lipid and protein-protein interactions triggered by specific signals, such as proteolytic cleavage or endosomal acidification. This Special Issue presents recent advances in characterizing functional, structural and thermodynamic aspects of the conformational switching and membrane interactions involved in the cellular entry of bacterial protein toxins. Deciphering the physicochemical principles underlying these processes is also a prerequisite for the use of protein engineering to develop toxin-based molecular vehicles capable of targeted delivery of therapeutic agents to tumors and other diseased tissues.