Name: Coumarin Derivatives (en Inglés)
Price: 73.53 USD
Availability: InStock
Author: Dighe, Nachiket ; Bhawar, Sanjay
ISBN: 9786202564151

portada Coumarin Derivatives (en Inglés)

Formato

Libro Físico

Autor

Nachiket Dighe

Sanjay Bhawar

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.6 cm

Peso

0.15 kg.

ISBN13

9786202564151

Categorías

Farmacología

Coumarin Derivatives (en Inglés)

Nachiket Dighe (Autor) · Sanjay Bhawar (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Coumarin Derivatives (en Inglés)"

The present research work deals with the synthesis, characterisation and to evaluate the synthesized compound for antidepressant activity of a series of coumarin derivatives. Basic coumarin is prepared by Perkin reaction, which further reacted with aryl thiourea by cyclization reaction leads to produce 3-(2-(phenylaminothiazol-4-yl)-2H-chromen-2-one. Totally twelve compounds, were synthesized by conventional method and their purity was determined by TLC and they were characterized by IR and NMR spectroscopic methods. Antidepressant activity of all the synthesized compounds was evaluated by despair swim test by using Sprague Dawley Rats. Standard drug Imipramine was used as the control. In the despair swim test, all the synthesized derivatives showed antidepressant activity. Among them three Compounds (A4, A5 and A9) showed significant antidepressant activity comparing with control drug imipramine and some compound shows mild antidepressant activity. These results are useful for the further investigation in the future.