Name: Dna-Encoded Chemical Libraries: Methods and Protocols (en Inglés)
SKU: 56471809
Price: 140.47 USD
Availability: InStock
Author: Israel, David ; Ding, Yun

portada Dna-Encoded Chemical Libraries: Methods and Protocols (en Inglés)

Dna-Encoded Chemical Libraries: Methods and Protocols (en Inglés)

Formato

Libro Físico

Editorial

Humana

Autor

Israel, David ; Ding, Yun

Idioma

Inglés

N° páginas

226

Encuadernación

Tapa Dura

Dimensiones

25.4x17.8x1.4 cm

Peso

0.63 kg.

ISBN13

9781071625446

Categorías

Genética (no médica)

Dna-Encoded Chemical Libraries: Methods and Protocols (en Inglés)

Israel, David ; Ding, Yun (Autor) · Humana · Tapa Dura

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Reseña del libro "Dna-Encoded Chemical Libraries: Methods and Protocols (en Inglés)"

This volume discusses protocols that cover synthesis, screening by selection, and analysis of DNA-encoded chemical libraries (DEL). Chapters in this book focus on methods used to practice DEL technology and include solution phase library synthesis using a variety of chemistries; DNA encoding of chemical structure; design, preparation and analysis of target proteins and tool compounds; screening of soluble protein targets by affinity selection; DEL qPCR, preparative PCR and DNA sequence analysis; computational methods used to analyze selections and choose compounds for resynthesis; and analysis of hit compounds. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, DNA-Encoded Chemical Libraries: Methods and Protocols is a valuable resource for scientists interested in DEL technology for drug discovery, and will contribute to the continued advancement in this important field.