Name: Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (en Inglés)
SKU: 57963546
Price: 62.81 USD
Availability: InStock
Author: Pulido, Rafael ; Lang, Roland

portada Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (en Inglés)

Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (en Inglés)

Formato

Libro Físico

Editorial

Mdpi AG

Autor

Pulido, Rafael ; Lang, Roland

Idioma

Inglés

N° páginas

240

Encuadernación

Tapa Blanda

Dimensiones

24.4x17x1.7 cm

Peso

0.52 kg.

ISBN13

9783039216888

Categorías

Biología, ciencias de la vida

Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (en Inglés)

Pulido, Rafael ; Lang, Roland (Autor) · Mdpi AG · Tapa Blanda

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Reseña del libro "Dual Specificity Phosphatases: From Molecular Mechanisms to Biological Function (en Inglés)"

Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.