Name: Gadd45 Stress Sensor Genes (en Inglés)
SKU: 60192274
Price: 177.96 USD
Availability: InStock
Author: Liebermann, Dan A. ; Hoffman, Barbara
ISBN: 9781493953905

portada Gadd45 Stress Sensor Genes (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Liebermann, Dan A. ; Hoffman, Barbara

Idioma

Inglés

N° páginas

134

Encuadernación

Tapa Blanda

Dimensiones

23.4x15.6x0.8 cm

Peso

0.21 kg.

ISBN13

9781493953905

Categorías

Anatomía
Fisiología
Genética médica
Bioquímica

Gadd45 Stress Sensor Genes (en Inglés)

Liebermann, Dan A. ; Hoffman, Barbara (Autor) · Springer · Tapa Blanda

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Reseña del libro "Gadd45 Stress Sensor Genes (en Inglés)"

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.