Name: Genetic Engineering: Principles and Methods (en Inglés)
SKU: 18950562
Price: 112.32 USD
Availability: InStock
Author: Setlow
ISBN: 9780306466458

portada Genetic Engineering: Principles and Methods (en Inglés)

Genetic Engineering: Principles and Methods (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Setlow

Año

2001

Idioma

Inglés

N° páginas

256

Encuadernación

Tapa Dura

ISBN

0306466457

ISBN13

9780306466458

N° edición

2001

Categorías

Genética médica

Genetic Engineering: Principles and Methods (en Inglés)

Setlow (Autor) · Springer · Tapa Dura

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Reseña del libro "Genetic Engineering: Principles and Methods (en Inglés)"

Over the past decade, our laboratory and others have been concerned with molecular archaeological studies aimed at revealing the origins and evolutionary histories of permeases (1). These studies have revealed that several different families, defined on the basis of sequence similarities, arose independently of each other, at different times in evolutionary history, following different routes. When complete microbial genomes first became available for analysis, we adapted p- existing software and designed new programs that allowed us quickly to identify probable transmembrane proteins, estimate their topologies and determine the likelihood that they function in transport (2). This work allowed us to expand previously-recognized families and to identify dozens of new families. All of this work then led us to attempt to design a rational but comprehensive classification system that would be applicable to the complete complement of transport systems found in all living organisms (3). The classification system that we have devised is based primarily on mode of transport and energy coupling mechanism, secondarily on molecular phylogeny, and lastly on the substrate specificities of the individual permeases (4).