Name: Mechanisms of ER Protein Import (en Inglés)
SKU: 54771002
Price: 70.88 USD
Availability: InStock
Author: Zimmermann, Richard ; Lang, Sven

portada Mechanisms of ER Protein Import (en Inglés)

Mechanisms of ER Protein Import (en Inglés)

Formato

Libro Físico

Editorial

Mdpi AG

Autor

Zimmermann, Richard ; Lang, Sven

Idioma

Inglés

N° páginas

258

Encuadernación

Tapa Dura

Dimensiones

24.4x17x2.1 cm

Peso

0.76 kg.

ISBN13

9783036540948

Categorías

Biología, ciencias de la vida

Mechanisms of ER Protein Import (en Inglés)

Zimmermann, Richard ; Lang, Sven (Autor) · Mdpi AG · Tapa Dura

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Reseña del libro "Mechanisms of ER Protein Import (en Inglés)"

Protein import into the endoplasmic reticulum (ER) is the first step in the biogenesis of approximately 10,000 different soluble and membrane proteins of human cells, which amounts to about 30% of the proteome. Most of these proteins fulfill their functions either in the membrane or lumen of the ER plus the nuclear envelope, in one of the organelles of the pathways for endo- and exocytosis (ERGIC, Golgi apparatus, endosome, lysosome, and trafficking vesicles), or at the cell surface as plasma membrane or secreted proteins. An increasing number of membrane proteins destined to lipid droplets, peroxisomes or mitochondria are first targeted to and inserted into the ER membrane prior to their integration into budding lipid droplets or peroxisomes or prior to their delivery to mitochondria via the ER-SURF pathway. ER protein import involves two stages, ER targeting, which guarantees membrane specificity, and the insertion of nascent membrane proteins into or translocation of soluble precursor polypeptides across the ER membrane. In most cases, both processes depend on amino-terminal signal peptides or transmembrane helices, which serve as signal peptide equivalents. However, the targeting reaction can also involve the ER targeting of specific mRNAs or ribosome-nascent chain complexes. Both processes may occur co- or post-translationally and are facilitated by various sophisticated machineries, which reside in the cytosol and the ER membrane, respectively. Except for resident ER and mitochondrial membrane proteins, the mature proteins are delivered to their functional locations by vesicular transport.