Name: Mif: A Most Interesting Factor (en Inglés)
SKU: 2640794
Price: 204.82 USD
Availability: InStock
Author: Bucala, Richard
ISBN: 9789812706485

portada Mif: A Most Interesting Factor (en Inglés)

Mif: A Most Interesting Factor (en Inglés)

Formato

Libro Físico

Editorial

World Scientific Publishing Company

Autor

Bucala, Richard

Idioma

Inglés

N° páginas

332

Encuadernación

Tapa Dura

Dimensiones

23.3x16.6x1.9 cm

Peso

0.64 kg.

ISBN

9812706488

ISBN13

9789812706485

Categorías

Inmunología
Patología

Mif: A Most Interesting Factor (en Inglés)

Bucala, Richard (Autor) · World Scientific Publishing Company · Tapa Dura

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Reseña del libro "Mif: A Most Interesting Factor (en Inglés)"

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.