Name: peptides as immunogens (en Inglés)
Price: 114.52 USD
Availability: InStock
Author: Koprowski, Hilary ; Melchers, Fritz
ISBN: 9783642714429

portada peptides as immunogens (en Inglés)

Formato

Libro Físico

Ilustrado por

Fritz Melchers

Hilary Koprowski

Editorial

Springer

Autor

Koprowski, Hilary ; Melchers, Fritz

Año

2011

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

24.4 x 17.0 x 0.5 cm

Peso

0.17 kg.

ISBN

3642714420

ISBN13

9783642714429

Categorías

Inmunología
Microbiología médica y virología
Bioquímica

peptides as immunogens (en Inglés)

Fritz Melchers (Ilustrado por) · Hilary Koprowski (Ilustrado por) · Springer · Tapa Blanda

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Reseña del libro "peptides as immunogens (en Inglés)"

The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho- cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an- tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro- teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym- phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be- come activated, they are ready to cooperate with B cells.