Name: Prions: Some Physiological and Pathophysiological Aspects (en Inglés)
SKU: 59800253
Price: 142.61 USD
Availability: InStock
Author: Sirakov, Ivo Nikolaev
ISBN: 9781789850178

portada Prions: Some Physiological and Pathophysiological Aspects (en Inglés)

Prions: Some Physiological and Pathophysiological Aspects (en Inglés)

Formato

Libro Físico

Editorial

Intechopen

Autor

Sirakov, Ivo Nikolaev

Idioma

Inglés

N° páginas

Encuadernación

Tapa Dura

Dimensiones

24.4x17x0.6 cm

Peso

0.34 kg.

ISBN13

9781789850178

Categorías

Enfermedades infectocontagiosas

Prions: Some Physiological and Pathophysiological Aspects (en Inglés)

Sirakov, Ivo Nikolaev (Autor) · Intechopen · Tapa Dura

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Reseña del libro "Prions: Some Physiological and Pathophysiological Aspects (en Inglés)"

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.