portada Pyrazoles: Synthesis and Biological Activity (en Inglés)

Pyrazoles: Synthesis and Biological Activity (en Inglés)

Formato

Libro Físico

Autor

Sobhi Gomha

Magda A. Abdallah

Ikhlass M. Abbas

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

180

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x1 cm

Peso

0.27 kg.

ISBN13

9786202525305

Categorías

Química orgánica

Pyrazoles: Synthesis and Biological Activity (en Inglés)

Sobhi Gomha (Autor) · Magda A. Abdallah (Autor) · Ikhlass M. Abbas (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Pyrazoles: Synthesis and Biological Activity (en Inglés)"

The original work of the present book consists of three research projects: In the first part: Synthesis, cytotoxicity evaluation, molecular docking and utility of novel chalcones as precursors for heterocycles incorporating pyrazole moiety.In the second part: Synthesis and antimicrobial activity of novel azolopyrimidines and pyrido-triazolo-pyrimidinones incorporating pyrazole moiety.In the third part: Synthesis of new pyrazolyl-pyridines as antitumor agents. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data and the mechanisms of their formation were also discussed. In addition, some of the newly synthesized chalcones were tested for their cytotoxicity against human colon carcinoma cell line (HCT-116) and against human hepatocellular carcinoma (HEPG2) cell lines and the results revealed that some compounds have promising activities compared with the standard drug Doxorubicin. Molecular docking was also carried out for the high potent compounds.