Name: Recent Advances in Transthyretin Evolution, Structure and Biological Functions (en Inglés)
SKU: 62114835
Price: 219.80 USD
Availability: InStock
Author: Richardson Samantha J.,Cody Vivian
ISBN: 9783642420719

portada Recent Advances in Transthyretin Evolution, Structure and Biological Functions (en Inglés)

Recent Advances in Transthyretin Evolution, Structure and Biological Functions (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Richardson Samantha J.,Cody Vivian

Idioma

Inglés

N° páginas

375

Encuadernación

Tapa Blanda

ISBN13

9783642420719

N° edición

2009th

Recent Advances in Transthyretin Evolution, Structure and Biological Functions (en Inglés)

Richardson Samantha J.,Cody Vivian (Autor) · Springer · Tapa Blanda

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Reseña del libro "Recent Advances in Transthyretin Evolution, Structure and Biological Functions (en Inglés)"

Since its ?rst description in 1942 in both serum and cerebrospinal ?uid, transthyretin (TTR) has had an eventful history, including changes in name from "prealbumin" to "thyroxine-binding prealbumin" to "transthyretin" as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver, choroid plexus (blood- cerebrospinal ?uid barrier), retinal pigment epithelium of the eye, pancreas, intestine and meninges. However, its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased, and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition, TTR binds retinol-binding protein, which binds retinol. In this way, TTR is also involved with retinoid distribution. More recently, TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs, pollutants, industrial compounds, heavy metals, and some naturally occurring plant ?avonoids. These not only interfere with thyroid hormone delivery in the body, but also transport such endocrine disruptors into the brain, where they have the potential to accumulate.