Name: steric fit in quantitative structure-activity relations (en Inglés)
SKU: 25912307
Price: 65.07 USD
Availability: InStock
Author: Balaban, A. T. ; Chiriac, A. ; Motoc, I.
ISBN: 9783540097556

portada steric fit in quantitative structure-activity relations (en Inglés)

steric fit in quantitative structure-activity relations (en Inglés)

Formato

Libro Físico

Autor

Editorial

Año

1980

Idioma

Inglés

N° páginas

178

Encuadernación

Tapa Blanda

Dimensiones

24.4x17x1.1 cm

Peso

0.32 kg.

ISBN

3540097554

ISBN13

9783540097556

Categorías

Química física

steric fit in quantitative structure-activity relations (en Inglés)

I. Motoc (Autor) · A. T. Balaban (Autor) · A. Chiriac (Autor) · Springer · Tapa Blanda

Libro Nuevo Importado

Envío: 16 a 23 días háb.

$ 108.45$ 65.07

-40%

Costos de importación incluídos en el precio ✅

Libro Nuevo

Quedan más de 100 unidades

$ 65.07

Llega entre el 07 Sep y el 18 Sep a Quito, Pichincha. Seleccionar ubicación

Agregar a lista de deseos

Reseña del libro "steric fit in quantitative structure-activity relations (en Inglés)"

Although the importance of steric fit for receptor-effector 1 interactions was recognized since Emil Fischer proposed his "lock and key" theory, the whole area of steric properties is still in a very 2-4 early stage of development. We have a fairly good idea about el- tronic and hydrophobic parameters, but it is not easy to describe ste- ric shapes of molecules without a large number of data. There are se- veral cases of good QSAR's developed for rather large series of mole- 5 cules without steric parameters - for example see papers by Hansch, 6 or Franke, but the state of steric parameters is nevertheless one of the most important drawbacks, especially concerning the ability of en- compassing, within a single QSAR, molecules of different shapes and stereoisomers. From today's steric parameters, one may mention the 7 Taft parameters E ' which gave good results in organic chemistry, the S 8 10 ra th er cum b ersome way 0 f measurIng - s h ape d'ff I ere h ces 0 f Amoore - and, 11 12 AllInger, and the L, B -B parameters of Verloop 1 4 The work described here consists of two types of approaches to the steric fit problem. The first approach consists of developing new parameters to describe different characteristics of the molecular shape (i. e., branching, bulkiness); this is done by means of topological in- dices.