Structure and Dynamics of Biological Molecules: Experimental and Theoretical Approaches (en Inglés) - Harekrushna Sahoo

This book presents the structures and dynamics of biomolecules such as proteins, carbohydrates, lipid membranes, RNA, and DNA, focusing on their interactions associated with various biological processes. The introductory chapter offers insights into the fundamental concepts and principles of biomolecular modeling and simulation and underscores their importance and scope in modern research. It provides an understanding of the historical evolution and contemporary challenges in force field development that govern the behavior of biomolecules. The chapters cover coarse-grained models for studying complex biomolecular assemblies and explore the power of Markov models in understanding dynamic processes within biomolecules. Furthermore, the book addresses practical applications of biomolecular modeling, with a focus on liposomes as drug delivery systems. It provides a detailed exploration of coarse-grained models, their development, and their applications in modeling complex biomolecular structures. Towards the end, the book discusses the modeling and simulation of DNA and RNA structures and their implications for drug discovery. This book is intended for researchers, scientists, and graduate students in the fields of molecular biology, biophysics, and computational chemistry.

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