portada Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (en Inglés)

Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (en Inglés)

Formato

Libro Físico

Autor

Youngjun Lee

Editorial

Springer

Idioma

Inglés

N° páginas

187

Encuadernación

Tapa Dura

Dimensiones

23.4x15.6x1.4 cm

Peso

0.48 kg.

ISBN13

9789811316449

Categorías

Biofísica
Química orgánica
Química industrial e ingeniería química

Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (en Inglés)

Youngjun Lee (Autor) · Springer · Tapa Dura

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Reseña del libro "Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (en Inglés)"

This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter. Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working underlive cell conditions. Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.