Name: Systemic protective responses to intranasal endotoxin application (en Inglés)
SKU: 66264409
Price: 63.55 USD
Availability: InStock
Author: Tselkova, Irina; Kulchitsky, Vladimir

portada Systemic protective responses to intranasal endotoxin application (en Inglés)

Systemic protective responses to intranasal endotoxin application (en Inglés)

Formato

Libro Físico

Editorial

Our Knowledge Publishing

Autor

Tselkova, Irina; Kulchitsky, Vladimir

Idioma

Inglés

N° páginas

132

Encuadernación

Tapa Blanda

Dimensiones

22.9x15.2x0.8 cm

ISBN13

9786209260001

Systemic protective responses to intranasal endotoxin application (en Inglés)

Tselkova, Irina; Kulchitsky, Vladimir (Autor) · Our Knowledge Publishing · Tapa Blanda

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Reseña del libro "Systemic protective responses to intranasal endotoxin application (en Inglés)"

This monograph presents the results of studies aimed at identifying the mechanisms controlling deep body temperature, metabolic intensity, behavioral activity, and nociceptive responses in rats following the application of Escherichia coli endotoxin to the nasal mucosa. The study proves for the first time that E. coli endotoxin penetrates the brain of laboratory rats after intranasal application, accompanied by a single- or two-phase rise in core body temperature, shifts in the intensity of metabolic processes, wave-like changes in behavioral activity, and the severity of nociceptive reactions. Based on the data obtained, an experimental model of the systemic inflammatory process was developed, initiated by the application of Escherichia coli endotoxin to the mucous membrane of the nasal cavity of rats. The model allows studying the mechanisms of the development of the systemic inflammatory process under conditions of natural contact of living organisms with lipopolysaccharides.