Name: Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (en Inglés)
SKU: 57259019
Price: 140.40 USD
Availability: InStock
Author: Bizzarri, Mariano

portada Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (en Inglés)

Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (en Inglés)

Formato

Libro Físico

Editorial

Springer

Autor

Bizzarri, Mariano

Idioma

Inglés

N° páginas

483

Encuadernación

Tapa Dura

Dimensiones

23.9x18.3x2.3 cm

Peso

0.82 kg.

ISBN13

9783030328566

Categorías

Oncología
Farmacología
Biología, ciencias de la vida

Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (en Inglés)

Bizzarri, Mariano (Autor) · Springer · Tapa Dura

Libro Nuevo Importado

Envío: 20 a 27 días háb.

$ 280.80$ 140.40

-50%

Costos de importación incluídos en el precio ✅

Libro Nuevo

Quedan más de 100 unidades

$ 140.40

Llega entre el 25 Sep y el 08 Oct a Quito, Pichincha. Seleccionar ubicación

Agregar a lista de deseos

Reseña del libro "Approaching Complex Diseases: Network-Based Pharmacology and Systems Approach in Bio-Medicine (en Inglés)"

This volume - for pharmacologists, systems biologists, philosophers and historians of medicine - points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.