Name: Cellular senescence, a multifaceted cellular state (en Inglés)
SKU: 58218822
Price: 57.93 USD
Availability: InStock
Author: Kobakozete Zezia, Joe
ISBN: 9786204133690

portada Cellular senescence, a multifaceted cellular state (en Inglés)

Cellular senescence, a multifaceted cellular state (en Inglés)

Formato

Libro Físico

Autor

Joe Kobakozete Zezia

Editorial

Our Knowledge Publishing

Idioma

Inglés

N° páginas

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.3 cm

Peso

0.09 kg.

ISBN13

9786204133690

Categorías

Medicina: cuestiones generales

Cellular senescence, a multifaceted cellular state (en Inglés)

Joe Kobakozete Zezia (Autor) · Our Knowledge Publishing · Tapa Blanda

Libro Nuevo Importado

Envío: 25 a 32 días háb.

$ 105.33$ 57.93

-45%

Costos de importación incluídos en el precio ✅

Libro Nuevo

Quedan 10 unidades

$ 57.93

Llega entre el 17 Sep y el 30 Sep a Quito, Pichincha. Seleccionar ubicación

Agregar a lista de deseos

Reseña del libro "Cellular senescence, a multifaceted cellular state (en Inglés)"

The aim of this book is to understand the impact that senescent cells can have on the process of remodeling of the extracellular matrix via the secretion of the secretory phenotype associated with senescence but also the consequences of this modification of the extracellular matrix on development. cancers and metastases.Different models of xenografts in vitro and in vivo in mice were used and showed a change in the level of mRNA expression of most factors associated with SASP such as IL-1α, IL-6, IL-8, MMP -1, MMP-3, MMP-10, MMP-12, VEGF etc. in senescent models compared to non-senescent models.These different factors secreted as a result of their overexpression promote excessive degradation of the extracellular matrix and chronic inflammation, the starting point for the occurrence of an epithelial-mesenchymal transition which in turn initiates the development of cancer cells.Thus, the therapeutic approach aimed at eliminating senescent cells using senolytic drugs seems to be effective during aging but also in the fight against age-related diseases associated with it.