Name: Epithelial-Mesenchymal Plasticity in Cancer Metastasis: Molecular Reprogramming, Cellular Adaptation, and Clinical Implications (en Inglés)
SKU: 57725545
Price: 116.10 USD
Availability: InStock
Author: Jolly, Mohit Kumar ; Celia-Terrassa, Toni
ISBN: 9783039367245

portada Epithelial-Mesenchymal Plasticity in Cancer Metastasis: Molecular Reprogramming, Cellular Adaptation, and Clinical Implications (en Inglés)

Epithelial-Mesenchymal Plasticity in Cancer Metastasis: Molecular Reprogramming, Cellular Adaptation, and Clinical Implications (en Inglés)

Formato

Libro Físico

Editorial

Mdpi AG

Autor

Jolly, Mohit Kumar ; Celia-Terrassa, Toni

Idioma

Inglés

N° páginas

512

Encuadernación

Tapa Dura

Dimensiones

24.4x17x4 cm

Peso

1.30 kg.

ISBN13

9783039367245

Categorías

Medicina: cuestiones generales

Epithelial-Mesenchymal Plasticity in Cancer Metastasis: Molecular Reprogramming, Cellular Adaptation, and Clinical Implications (en Inglés)

Jolly, Mohit Kumar ; Celia-Terrassa, Toni (Autor) · Mdpi AG · Tapa Dura

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Reseña del libro "Epithelial-Mesenchymal Plasticity in Cancer Metastasis: Molecular Reprogramming, Cellular Adaptation, and Clinical Implications (en Inglés)"

Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.