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Polyomavirus nephritis (en Inglés)
Meriam Khadhar
(Autor)
·
Soumaya Chargui
(Autor)
·
David Buob
(Autor)
·
Our Knowledge Publishing
· Tapa Blanda
Polyomavirus nephritis (en Inglés) - Khadhar, Meriam ; Chargui, Soumaya ; Buob, David
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Reseña del libro "Polyomavirus nephritis (en Inglés)"
Polyomavirus nephritis (PVAN) is one of the most common viral complications in renal transplantation. It is in more than 97% of cases caused by BK virus in the context of BK virus nephritis and in less than 2% caused by JC virus. PVAN leads to graft loss in 30 to 80% of cases. Early diagnosis is therefore necessary to modify the immunosuppressive treatment and avoid graft loss. The diagnosis of PVAN is histological and combines tubulo-interstitial inflammation and a viral cytopathic effect in the form of nuclear inclusions of tubular cells. Tubular cell infection can be highlighted by immunohistochemical evidence of Sv-40 viral antigen expression. PVAN has histologic similarities to acute cellular rejection, but the resulting treatments are diametrically opposed. One requires a decrease in immunosuppression, while the other requires an increase in immunosuppression, so accurate and early diagnosis is a major challenge.
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