Name: Antioxidant Effect of Trolox in Diabetic Rat: Pharmacological Evaluation (en Inglés)
Price: 66.79 USD
Availability: InStock
Author: Shivshankar Mhaske; Mahesh Narkhede; Vinayak Shrikhande
ISBN: 9783330650824

portada Antioxidant Effect of Trolox in Diabetic Rat: Pharmacological Evaluation (en Inglés)

Formato

Libro Físico

Editorial

Sps

Autor

Shivshankar Mhaske; Mahesh Narkhede; Vinayak Shrikhande

Año

2017

Idioma

Inglés

N° páginas

124

Encuadernación

Tapa Blanda

ISBN13

9783330650824

Antioxidant Effect of Trolox in Diabetic Rat: Pharmacological Evaluation (en Inglés)

Shivshankar Mhaske; Mahesh Narkhede; Vinayak Shrikhande (Autor) · Sps · Tapa Blanda

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Reseña del libro "Antioxidant Effect of Trolox in Diabetic Rat: Pharmacological Evaluation (en Inglés)"

The present study was undertaken to evaluate effect of trolox on antioxidant status in STZ induced diabetic rats. All animals were divided into four groups and diabetes was induced by STZ (45 mg/kg, i.p) in all groups. Animals received trolox 10 mg/kg and 20 mg/kg respectively for seven days. After 48 hrs of administration of STZ blood glucose levels was estimated. Animals having blood glucose levels more than 200 mg/dl were selected for study. On 8th day, blood was withdrawn by puncturing retro orbital sinus and centrifuged at 3000 rpm for 10 min to separate serum which was used for determination of antioxidant enzymes, lipid peroxidation (MDA) and uric acid level. Our present study revealed that antioxidant enzymes like SOD, CAT and peroxidase were reduced significantly in diabetic rats as compared to normal control rats. Lipid peroxidation and uric acid levels were significantly increased as compared to normal control animals. Administration of trolox (10 mg/kg and 20 mg/kg, i.p) for seven days could significantly elevated reduced activities of SOD, CAT and peroxidase and decreased elevated levels of MDA and uric acid. It is concluded that trolox can possess antioxidant activity.